Physical limits to spatial resolution of optical recording: Clarifying the spatial structure of cortical hypercolumns SUPPORTING TEXT
نویسندگان
چکیده
Monte Carlo techniques are the primary method for modeling the behavior of light in biological tissue. They were first applied in this context to modeling the interaction of laser light with tissue in medical applications for the assessment of damage during clinical laser ablation (2). The term Monte Carlo (3) refers to the use of a stochastic simulation to model physical processes. It is well understood and widely deployed. However, since the tissue ablation literature assumes the existence of a tightly collimated laser beam, and the current application requires examination of individual photon paths, we wrote a custom version of the basic photon scattering and absorption model in the MATLAB development environment (MathWorks, Natick, MA).
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Physical limits to spatial resolution of optical recording: clarifying the spatial structure of cortical hypercolumns.
Neurons in macaque primary visual cortex are spatially arranged by their global topographic position and in at least three overlapping local modular systems: ocular dominance columns, orientation pinwheels, and cytochrome oxidase (CO) blobs. Individual neurons in the blobs are not tuned to orientation, and populations of neurons in the pinwheel center regions show weak orientation tuning, sugge...
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